The Lakers (37-7-4) took the match, winning 25-22, 25-9 and 25-12.
Haley Howell had 33 assists, 13 digs, six aces, four kills and three blocks for Our Lady, while Courtney Wightman had 12 kills, 12 digs and an ace.
Allison Samulon also had seven kills, five aces, four digs and a block, while Abbigayle Kline had four aces, four kills, four digs and two blocks, and Kristina Krupiak had 10 kills, five digs and an ace.
The Lakers played in a Class D state quarter-final match against Beal City at Mt. Morris on Tuesday, Nov. 13, after press time.
The winner will advance to the Class D state semi-finals at Kellogg Arena in Battle Creek on Friday, Nov. 16.
The Class D state final is on Saturday, Nov. 17.
Our Lady advanced to the regional final with a three-game sweep of Detroit Catholic League rival Marine City Cardinal Mooney, 25-23, 25-11 and 25-21, on Tuesday, Nov. 6.
Devon Valen and Angela Ludlow each had five kills and four aces, while Samulon had eight kills and two aces and Wightman had 10 kills, seven digs and three blocks.